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Bonnie,
I'd suggest checking out Pat Hasting's book, Tricks of the Trade. As for clinical trials, well given the number of Breeders who seek her out for evaluations (I can think of one source where there are 2,000 members or so) and Breeders who are following her protocols with great success in healthy sound puppies growing into healthy sound adults, the "clinical" trials have been done and each new litter evaluation only adds to her data.
Debbie
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