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Kris L. Christine · 03-07-2008, 06:02 AM

I came across the article below recently, and this research really frightens me because they are trying to develop a Modified LIVE Rabies Vaccine. MLV vaccines can and do convert to virulence.

Under the "Immunological Factors Determining Vaccine Safety" column on page 16 of the American Animal Hospital Association's 2003 Canine Vaccine Guidelines it is written that: [b]" Modified live virus vaccines can and do cause dis-ease because attenuation is a balance between maintaining infectivity while eliminating its pathogenicity. Individual response is dependent on the status of the recipient’s immune system. Thus, an attenuated pathogen in a host which is severely immunosuppressed, or genetically more susceptible, may result in the vaccine causing the disease for which it was designed to prevent. ."

UGA receives grant for rabies vaccine study - - DVM

UGA receives grant for rabies vaccine study

Dec 1, 2007
DVM Newsmagazine

ATHENS, GA. — The University of Georgia (UGA) College of Veterinary Medicine received a $1.18 million grant to develop rabies-virus vaccinations.

Awarded by the National Institute of Allergy and Infectious Disease (NIAID) at the National Institutes of Health, the grant is the continuation of a four-year, $837,000 NIAID grant issued in 2002 to initiate the study.

The goal is a less expensive and invasive way of vaccinating humans and animals from rabies.

The proposed vaccine will use a genetically modified form of the live virus that allows the body to establish immunity without actually catching the virus.

"We propose to develop a live form of vaccine by incorporating immune-stimulatory molecules into the virus genome," says lead investigator Zhen Fu, UGA professor of veterinary pathology. "By doing so, we expect to develop a vaccine with greater potency, yet reduced cost, because fewer doses will be needed for immunity. The vaccines also can be used in domestic and wild animals to protect them from rabies."
__________________________________________________ _____________
Duration of Immunity to Canine Vaccines: What We Know and Don't Know, Dr. Ronald Schultz Duration of Immunity

World Small Animal Veterinary Association 2007 Vaccine Guidelines http://www.wsava.org/SAC.htmScroll down to Vaccine Guidelines 2007 (PDF)

The 2003 American Animal Hospital Association's Canine Vaccine Guidelines are accessible online at Special Report .

The 2006 American Animal Hospital Association's Canine Vaccine Guidelines are downloadable in PDF format at About AAHA .

Veterinarian, Dr. Robert Rogers,has an excellent presentation on veterinary vaccines at Home

03-07-2008, 06:02 AM	#31 (permalink)
Kris L. Christine Member Join Date: Feb 2008 Location: THE RABIES CHALLENGE FUND Posts: 53	I came across the article below recently, and this research really frightens me because they are trying to develop a Modified LIVE Rabies Vaccine. MLV vaccines can and do convert to virulence. Under the "Immunological Factors Determining Vaccine Safety" column on page 16 of the American Animal Hospital Association's 2003 Canine Vaccine Guidelines it is written that: [b]" Modified live virus vaccines can and do cause dis-ease because attenuation is a balance between maintaining infectivity while eliminating its pathogenicity. Individual response is dependent on the status of the recipient’s immune system. Thus, an attenuated pathogen in a host which is severely immunosuppressed, or genetically more susceptible, may result in the vaccine causing the disease for which it was designed to prevent. ." UGA receives grant for rabies vaccine study - - DVM UGA receives grant for rabies vaccine study Dec 1, 2007 DVM Newsmagazine ATHENS, GA. — The University of Georgia (UGA) College of Veterinary Medicine received a $1.18 million grant to develop rabies-virus vaccinations. Awarded by the National Institute of Allergy and Infectious Disease (NIAID) at the National Institutes of Health, the grant is the continuation of a four-year, $837,000 NIAID grant issued in 2002 to initiate the study. The goal is a less expensive and invasive way of vaccinating humans and animals from rabies. The proposed vaccine will use a genetically modified form of the live virus that allows the body to establish immunity without actually catching the virus. "We propose to develop a live form of vaccine by incorporating immune-stimulatory molecules into the virus genome," says lead investigator Zhen Fu, UGA professor of veterinary pathology. "By doing so, we expect to develop a vaccine with greater potency, yet reduced cost, because fewer doses will be needed for immunity. The vaccines also can be used in domestic and wild animals to protect them from rabies." __________________________________________________ _____________ Duration of Immunity to Canine Vaccines: What We Know and Don't Know, Dr. Ronald Schultz Duration of Immunity World Small Animal Veterinary Association 2007 Vaccine Guidelines http://www.wsava.org/SAC.htmScroll down to Vaccine Guidelines 2007 (PDF) The 2003 American Animal Hospital Association's Canine Vaccine Guidelines are accessible online at Special Report . The 2006 American Animal Hospital Association's Canine Vaccine Guidelines are downloadable in PDF format at About AAHA . Veterinarian, Dr. Robert Rogers,has an excellent presentation on veterinary vaccines at Home